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Metal Toxicology Handbook

Edited by: Debasis Bagchi , Manashi Bagchi

Print publication date:  November  2020
Online publication date:  November  2020

Print ISBN: 9781138345249
eBook ISBN: 9780429438004
Adobe ISBN:

10.1201/9780429438004
 Cite  Marc Record

Book description

Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson?s and Alzheimer?s diseases, cardiovascular disorders, and several others.

Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting.

Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals.

Key Features

  • Discusses the pathology of metal toxicity
  • Highlights the benefits of metals
  • Explains the mechanism and salient features of restoring metabolic homeostasis
  • Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity

The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals.

The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

Table of contents

Prelims Download PDF
Chapter  1:  Role of Metals and Metalloids in Redox Biology  Download PDF
Chapter  2:  Role of Metals in Neurodegeneration Download PDF
Chapter  3:  Pathological Manifestations and Mechanisms of Metal Toxicity Download PDF
Chapter  4:  An Overview of Heavy Metal Research in Traditional Chinese Medicine Download PDF
Chapter  5:  Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis Download PDF
Chapter  6:  Gut Microbiome and Heavy Metals Download PDF
Chapter  7:  A Review on Radionuclide Toxicity Download PDF
Chapter  8:  Contribution of Bioavailable Silicon in Human Health Download PDF
Chapter  9:  Benefits of Trivalent Chromium in Human Nutrition? Download PDF
Chapter  10:  Trivalent Chromium Download PDF
Chapter  11:  Differential Impact of Organic Vanadium Compounds on Human Health Download PDF
Chapter  12:  Vanadium—Speciation Chemistry Can Be Important When Assessing Health Effects on Living Systems Download PDF
Chapter  13:  Clinical Toxicology of Copper Download PDF
Chapter  14:  Cadmium Exposure and Toxicity Download PDF
Chapter  15:  Cobalt Toxicity and Human Health Download PDF
Chapter  16:  Cobalt Toxicity Download PDF
Chapter  17:  Iron-Siderophore and Tumorigenesis Download PDF
Chapter  18:  Clinical Toxicology of Iron Download PDF
Chapter  19:  Vanadium Toxicity Revisited Download PDF
Chapter  20:  The Ubiquitous Lead—Biological Effects, Toxicity, and Management Download PDF
Chapter  21:  Lead Toxicity Download PDF
Chapter  22:  Arsenic Toxicity Download PDF
Chapter  23:  Clinical Toxicology of Mercury Download PDF
Chapter  24:  An Overview of Tungsten Toxicity Download PDF
Chapter  25:  Boron Toxicity Download PDF
Chapter  26:  Diversity of Mechanisms for Boron Toxicity in Mammals Download PDF
Chapter  27:  Lithium Download PDF
Chapter  28:  An Overview of Nickel Toxicity in Plants Download PDF
Chapter  29:  Commentary Download PDF
Index Download PDF
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