Nanomaterials for the Delivery of Therapeutic Nucleic Acids

Authored by: Michael Riley , Wilfred Vermerris

21 Century Nanoscience – A Handbook

Print publication date:  April  2020
Online publication date:  April  2020

Print ISBN: 9780815357070
eBook ISBN: 9780429351587
Adobe ISBN:

10.1201/9780429351587-5

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Abstract

Recent advances in medicine and genetics have made it possible to diagnose and treat genetic disorders and cancer by modulating gene expression. This requires the ability to deliver therapeutic nucleic acids to specific tissues or cells within the body with minimal side effects, while avoiding the body’s ability to clear foreign materials and viruses used for delivery. As a complement to viral delivery vectors, nanomedicine research has developed an array of novel delivery systems. These nanomaterial-based vectors can be synthesized from inorganic nanomaterials, carbon-based nanomaterials, lipid-based nanomaterials, protein- and peptide-based nanomaterials, and polymeric nanomaterials. In addition to their ease of design and tunable properties, benefits over viral vectors are reduced immunogenicity, the ability to deliver a more diverse set of therapeutic nucleic acids, and low cytotoxicity.

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