Genetic Engineering as a Tool for Enhanced PHA Biosynthesis from Inexpensive Substrates

Authored by: Lorenzo Favaro , Tiziano Cazzorla , Marina Basaglia , Sergio Casella

The Handbook of Polyhydroxyalkanoates

Print publication date:  November  2020
Online publication date:  November  2020

Print ISBN: 9780367275594
eBook ISBN: 9780429296611
Adobe ISBN:


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Large-scale production of polyhydroxyalkanoates (PHA) is mainly limited by the high cost of the raw materials used as substrates. However, huge amounts of inexpensive residues, such as whey, molasses, waste glycerol and lipids, and starchy and lignocellulosic substrates, are available and could be potentially used for industrial PHA production. Unfortunately, wild-type strains for the direct and efficient conversion of low-cost waste streams into PHA are not available in nature, and therefore the engineering of strains became the key factor.

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