Purification of Glycoproteins and Analyses of their Oligosaccharides

Authored by: Ahmed Hafiz

Principles and Reactions of Protein Extraction, Purification, and Characterization

Print publication date:  September  2004
Online publication date:  September  2004

Print ISBN: 9780849320347
eBook ISBN: 9780203507438
Adobe ISBN:

10.1201/9780203507438.ch7

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Abstract

Glycoproteins constitute the class of glycoconjugates in which glycans (carbohydrate moieties) are covalently associated with the proteins, usually through the N atom of asparagines (N-glycans) or the O atom of serine/threonine (O-glycans). Glycosyla-tion of proteins represents one of the most common and important post-translational phenomenons. Most proteins in an organism are glycoproteins. Glycans in glycoproteins are known to play several biological roles. Some examples are the protection of the protein from proteolysis attack; cell-cell interactions through lectins; association with enzymes, bacteria, and viruses; and maintaining protein conformation in a biologically active form.

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