Zeta Potential

Authored by: Luk Chiu Li

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v5-51

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Abstract

Dispersion systems represent an important class of pharmaceutical dosage forms such as emulsions, suspensions, microspheres, liposomes, and nanoparticles. The medium of these systems is mainly aqueous in nature and the dispersed phase can be either solid particles or immiscible liquid droplets. Electrical charges are developed by several mechanisms at the interface between the dispersed phase and the aqueous medium (1). The two most common mechanisms are the ionization of surface functional groups and the specific adsorption of ions. These electrical charges play an important role in determining the interaction between particles of the dispersed phase and the resultant physical stability of the systems, particularly for those in the colloidal size range. For dispersed systems which are used as drug carriers, their in vivo fate and therapeutic efficacy are both affected by these surface charges. Therefore, the understanding of this electrical phenomenon becomes essential in developing these systems.

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