Thermal Analysis of Drugs and Drug Products

Authored by: Danièlle Giron

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v5-32

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Abstract

Thermal analysis techniques, in which a physical property is monitored as a function of temperature or time while the analyte is heated or cooled under controlled conditions, are fundamental techniques for the characterization of drugs and drug products, not only while processing or aging conditions may be simulated but while the methods gives access to thermodynamic data. Due to the different informations delivered, thermal analysis methods are concurrent or complementary to other analytical techniques, such as spectroscopy, chromatography, melting, loss on drying, assay, for identification, purity, and quantitation. They are basic methods in the field of polymer analysis and in physical and chemical characterization of pure substances as well as for mixtures. They find good applications for preformulation, processing, and control of the drug product. The introduction of automation considerably increases the advantages of these methods. New horizons are open with the availability of combined techniques and microthermal analysis.

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