Abstract

Therapeutic drugs are often given systemically. Once given systemically, a drug will distribute throughout the body. By distributing in the body, the drug is essentially diluted out from its original concentration in the formulation/dosage form. Hence, the formulation is really a drug concentrate. For solid dosage forms, the dose to be delivered is not normally a physical problem. However, dose can become a significant formulation challenge for parenteral preparations, due to limitations in aqueous solubility and volume. Therefore, in order to obtain a solution formulation for drugs with poor solubility, it is necessary to alter the formulation to facilitate solubilization.