Solubilization of Drugs in Aqueous Media

Authored by: Paul B. Myrdal , Samuel H. Yalkowsky

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v5-2

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Abstract

Therapeutic drugs are often given systemically. Once given systemically, a drug will distribute throughout the body. By distributing in the body, the drug is essentially diluted out from its original concentration in the formulation/dosage form. Hence, the formulation is really a drug concentrate. For solid dosage forms, the dose to be delivered is not normally a physical problem. However, dose can become a significant formulation challenge for parenteral preparations, due to limitations in aqueous solubility and volume. Therefore, in order to obtain a solution formulation for drugs with poor solubility, it is necessary to alter the formulation to facilitate solubilization.

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