Radiolabeling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition

Authored by: Hak-Kim Chan , William Glover , Stefan Eberl

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v4-43

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Abstract

Inhalation aerosols have been successfully used to deliver drugs to the lung for local and systemic therapeutic effects. In vivo evaluation of pharmaceutical inhalation products is achieved by gamma scintigraphic imaging of the aerosol deposited in the lungs. Imaging provides direct information on the amount and the location of the drug deposited in the lungs after inhalation (1). This local bioavailability, rather than the systemic bioavailability after absorption, is pertinent to drugs that act directly on the lungs. For drugs that act systemically, the deposition site affects the rate and extent of absorption. As a result, lung deposition using gamma scintigraphy has been proposed for bioequivalence studies of aerosol products (2). The deposition data can further be linked to the clinical response and in vitro particle size distribution, adding a new dimension to the interrelationship between them.

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