Prodrug Design

Authored by: Bernard Testa , Joachim Mayer

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v4-35

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Abstract

Drug disposition and metabolism are of essential significance in pharmaceutical research because of the interdependence of pharmacokinetic and pharmacodynamic processes. Limited intestinal absorption, inadequate distribution, fast metabolism, and toxic metabolites are some of the causes of failure of drug candidates during development. To reduce the rate of attrition resulting from such pharmacokinetic defects, disposition and metabolic studies should be initiated as early as possible in the screening of lead candidates.

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