Population Pharmacokinetics

Authored by: Ene I. Ette , Alaa M. Ahmad , Paul J. Williams

Encyclopedia of Pharmaceutical Science and Technology

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4-v4-31

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Abstract

Population pharmacokinetics (PPK) is an area of clinical pharmacology, which aims at the quantitative assessment of between and within individual variability in drug absorption, distribution, metabolism, and excretion. The purpose of PPK is to provide quantitative guidelines for dosage individualization/optimization. Recognizing the importance of resolving these issues in drug development has led to a surge in the application of PPK to new drug development and the regulatory process.

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