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Encyclopedia of Pharmaceutical Science and Technology

Edited by: James Swarbrick

Print publication date:  July  2013
Online publication date:  July  2013

Print ISBN: 9781841848198
eBook ISBN: 9781351124874
Adobe ISBN:

10.1081/E-EPT4
 Cite  Marc Record

Book description

Pharmaceutical science deals with the whole spectrum of drug development from start to finish. There are many different facets to the pharmaceutical industry, from initial research to the finished product, including the equipment used, trials performed, and regulations that must be followed. Presenting an overview of all of these different aspects, the Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition is a must-have reference guide for all laboratories and libraries in the pharmaceutical field. Bringing together leaders from every specialty related to pharmaceutical science and technology, this is the single-source reference at the forefront of pharmaceutical R&D.

The strength of this work is not only its breadth but also the caliber of contributing writers, all experts in their field, writing on all aspects of pharmaceutical science and technology. The fourth edition offers 29 new chapters ranging from biomarkers, computational chemistry, and contamination control to high-throughput screening, orally disintegrating tablets, and quality by design. The encyclopedia details best practices of equipment used, methods for manufacturing, options for packaging, and routes for drug delivery. The volumes also provide a thorough understanding of the choices behind each method. In addition, the regulations, safety aspects, patent guidance, and methods of analysis are presented.

Key Areas Covered:

  • Analytics
  • Biomarkers
  • Dosage forms
  • Drug delivery
  • Formulation
  • Informatics
  • Manufacturing
  • Packaging
  • Processing
  • Regulatory affairs
  • Systems validation

This is an authoritative reference source for those practicing in any area of pharmaceutical science and technology, enabling the pharmaceutical specialist and novice alike to keep abreast of developments in this constantly evolving and highly competitive field.

Also Available Online
This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including:

  • Citation tracking and alerts
  • Active reference linking
  • Saved searches and marked lists
  • HTML and PDF format options

Contact Taylor and Francis for more information or to inquire about subscription options and print/online combination packages.
US: (Tel) 1.888.318.2367; (E-mail) [email protected]
International: (Tel) +44 (0) 20 7017 6062; (E-mail) [email protected]

Table of contents

Prelims Download PDF
Chapter  1:  Absorption Enhancers Download PDF
Chapter  2:  Absorption of Drugs Download PDF
Chapter  3:  Absorption of Drugs Download PDF
Chapter  4:  Adsorption at Solid Surfaces: Pharmaceutical Applications Download PDF
Chapter  5:  Adverse Drug Reactions Download PDF
Chapter  6:  Advertising and Promotion of Prescription and Over-the-Counter Drug Products Download PDF
Chapter  7:  Amorphous Pharmaceutical Systems Download PDF
Chapter  8:  Analysis of Biologic Fluids Download PDF
Chapter  9:  Analytical Procedures: Validation Download PDF
Chapter  10:  Animals in Drug Development Download PDF
Chapter  11:  Automated Dissolution Testing Download PDF
Chapter  12:  Autoxidation and Antioxidants Download PDF
Chapter  13:  Bioavailability and Bioequivalence Download PDF
Chapter  14:  Biodegradable Polymers as Drug Carriers Download PDF
Chapter  15:  Biomarkers in Drug Discovery and Development Download PDF
Chapter  16:  Biopharmaceutics Download PDF
Chapter  17:  Biosynthesis of Drugs Download PDF
Chapter  18:  Biotechnology and Biological Preparations Download PDF
Chapter  19:  Biotechnology-Derived Drug Products: Formulation Development Download PDF
Chapter  20:  Biotechnology-Derived Drug Products: Stability Testing, Filling, and Packaging Download PDF
Chapter  21:  Biotransformation of Drugs Download PDF
Chapter  22:  Bio-Validation of Steam Sterilization Download PDF
Chapter  23:  Blood Substitutes: Fluorocarbon Approach Download PDF
Chapter  24:  Blood Substitutes: Hemoglobin-Based Oxygen Carriers Download PDF
Chapter  25:  Blow-Fill-Seal: Advanced Aseptic Processing Download PDF
Chapter  26:  Buffers, Buffering Agents, and Ionic Equilibria Download PDF
Chapter  27:  Calorimetry in Pharmaceutical Research and Development Download PDF
Chapter  28:  Capsules, Hard Download PDF
Chapter  29:  Capsules, Soft Download PDF
Chapter  30:  Carcinogenicity Testing Strategy: Past, Present, and Future Download PDF
Chapter  31:  Chiroptical Analytical Methods Download PDF
Chapter  32:  Chromatographic Methods of Analysis: Gas Chromatography Download PDF
Chapter  33:  Chromatographic Methods of Analysis: High-Performance Liquid Chromatography Download PDF
Chapter  34:  Chromatographic Methods of Analysis: Thin Layer Chromatography Download PDF
Chapter  35:  Clinical Evaluation of Drugs Download PDF
Chapter  36:  Clinical Pharmacokinetics and Pharmacodynamics Download PDF
Chapter  37:  Clinical Supplies Manufacture: GMP Considerations Download PDF
Chapter  38:  Coacervation and Phase Separation Download PDF
Chapter  39:  Cocrystals: Design, Properties and Formation Mechanisms Download PDF
Chapter  40:  Colloids and Colloid Drug Delivery System Download PDF
Chapter  41:  Coloring Agents for Use in Pharmaceuticals Download PDF
Chapter  42:  Complexation: Cyclodextrins Download PDF
Chapter  43:  Complexation: Non-Cyclodextrins Download PDF
Chapter  44:  Computational Chemistry Download PDF
Chapter  45:  Computer Systems Validation Download PDF
Chapter  46:  Computer-Assisted Drug Design Download PDF
Chapter  47:  Contamination Control: Cleanrooms and Clean Air Devices Download PDF
Chapter  48:  Continuous Processing of Pharmaceuticals Download PDF
Chapter  49:  Control of Genotoxic Impurities in Pharmaceutical Products Download PDF
Chapter  50:  Cooling Processes and Congealing Download PDF
Chapter  51:  Coprecipitates, Melts and Solid Dispersions Download PDF
Chapter  52:  Corrosion of Pharmaceutical Equipment Download PDF
Chapter  53:  Cosolvents and Cosolvency Download PDF
Chapter  54:  Crystal Form Analysis of Drug Substances Download PDF
Chapter  55:  Crystal Habit Changes and Dosage Form Performance Download PDF
Chapter  56:  Crystallization: General Principles and Significance on Product Development Download PDF
Chapter  57:  Crystallization: Particle Size Control Download PDF
Chapter  58:  Dendrimers Download PDF
Chapter  59:  Dental Products Download PDF
Chapter  60:  Dissolution and Dissolution Testing Download PDF
Chapter  61:  Dosage Form Design: A Physicochemical Approach Download PDF
Chapter  62:  Dosage Forms: Non-Parenteral Download PDF
Chapter  63:  Dosage Forms: Parenterals Download PDF
Chapter  64:  Dosing of Drugs: Dosage Regimens and Dose-Response Download PDF
Chapter  65:  Dressings in Wound Management Download PDF
Chapter  66:  Drug Delivery Systems: Neutron Scattering Studies Download PDF
Chapter  67:  Drug Delivery using Electrophoresis Download PDF
Chapter  68:  Drug Delivery: Buccal Route Download PDF
Chapter  69:  Drug Delivery: Controlled Release Download PDF
Chapter  70:  Drug Delivery: Fast Dissolve Systems Download PDF
Chapter  71:  Drug Delivery: Gastro-Retentive Systems Download PDF
Chapter  72:  Drug Delivery: Inner Ear Download PDF
Chapter  73:  Drug Delivery: Liquid Crystals Download PDF
Chapter  74:  Drug Delivery: Monoclonal Antibodies Download PDF
Chapter  75:  Drug Delivery: Mucoadhesive Systems Download PDF
Chapter  76:  Drug Delivery: Nasal Route Download PDF
Chapter  77:  Drug Delivery: Needle-Free Systems Download PDF
Chapter  78:  Drug Delivery: Ophthalmic Route Download PDF
Chapter  79:  Drug Delivery: Oral Colon-Specific Download PDF
Chapter  80:  Drug Delivery: Oral Route Download PDF
Chapter  81:  Drug Delivery: Parenteral Route Download PDF
Chapter  82:  Drug Delivery: Pulmonary Delivery Download PDF
Chapter  83:  Drug Delivery: Pulsatile Systems Download PDF
Chapter  84:  Drug Delivery: Rectal Route Download PDF
Chapter  85:  Drug Delivery: Targeted Delivery with Monoclonal Antibodies Download PDF
Chapter  86:  Drug Delivery: Topical and Transdermal Routes Download PDF
Chapter  87:  Drug Delivery: Tumor-Targeted Systems Download PDF
Chapter  88:  Drug Delivery: Vaginal Route Download PDF
Chapter  89:  Drug Design: Basic Principles and Applications Download PDF
Chapter  90:  Drug Information Systems Download PDF
Chapter  91:  Drug Master Files Download PDF
Chapter  92:  Drug Transporters in ADME Download PDF
Chapter  93:  Dry Powder Aerosols: Emerging Technologies Download PDF
Chapter  94:  Drying and Dryers Download PDF
Chapter  95:  Effervescent Pharmaceuticals Download PDF
Chapter  96:  Elastomeric Components for the Pharmaceutical Industry Download PDF
Chapter  97:  Electroanalytical Methods of Analysis: Polarography and Voltammetry Download PDF
Chapter  98:  Electroanalytical Methods of Analysis: Potentiometry Download PDF
Chapter  99:  Electrochemical Detection for Pharmaceutical Analysis Download PDF
Chapter  100:  Electrostatic Charge in Pharmaceutical Systems Download PDF
Chapter  101:  Emulsions and Microemulsions Download PDF
Chapter  102:  Enzyme Immunoassay and Related Bioanalytical Methods Download PDF
Chapter  103:  Equipment Cleaning Download PDF
Chapter  104:  European Medicines Agency (EMA) Download PDF
Chapter  105:  Evaporation and Evaporators Download PDF
Chapter  106:  Evolutionary Computing and Formulation Optimization Download PDF
Chapter  107:  Excipients for Pharmaceutical Dosage Forms Download PDF
Chapter  108:  Excipients: Parenteral Dosage Forms and Their Role Download PDF
Chapter  109:  Excipients: Powders and Solid Dosage Forms Download PDF
Chapter  110:  Excipients: Safety Testing Download PDF
Chapter  111:  Expert Systems in Pharmaceutical Product Development Download PDF
Chapter  112:  Extractables and Leachables in Drugs and Packaging Download PDF
Chapter  113:  Extrusion and Extruders Download PDF
Chapter  114:  Film Coating of Oral Solid Dosage Forms Download PDF
Chapter  115:  Filters and Filtration Download PDF
Chapter  116:  Flavors and Flavor Modifiers Download PDF
Chapter  117:  Flow Properties of Solids Download PDF
Chapter  118:  Fluid Bed Processes for Forming Functional Particles Download PDF
Chapter  119:  Food and Drug Administration: Role in Drug Regulation Download PDF
Chapter  120:  Fractal Geometry in Pharmaceutical and Biological Applications Download PDF
Chapter  121:  Freeze Drying of Biologics Download PDF
Chapter  122:  Freeze Drying of Pharmaceuticals Download PDF
Chapter  123:  Freeze Drying: Scale-Up Considerations Download PDF
Chapter  124:  Generic Drug Products and Therapeutic Equivalence Download PDF
Chapter  125:  Genetic Aspects of Drug Development Download PDF
Chapter  126:  Geriatric Dosing and Dosage Forms Download PDF
Chapter  127:  Good Clinical Practices (GCPs)-An Overview Download PDF
Chapter  128:  Good Laboratory Practice (GLP)-An Overview Download PDF
Chapter  129:  Good Manufacturing Practices (GMPs) – An Overview Download PDF
Chapter  130:  Good Publication Practice Download PDF
Chapter  131:  Handling Hazardous Chemicals and Pharmaceuticals Download PDF
Chapter  132:  Headspace Oxygen Analysis in Pharmaceutical Products Download PDF
Chapter  133:  Health Care Systems Outside the U.S.A. Download PDF
Chapter  134:  High-Throughput Screening (HTS) in Drug Discovery Download PDF
Chapter  135:  Homogenization and Homogenizers Download PDF
Chapter  136:  Hot-Melt Extrusion Technology Download PDF
Chapter  137:  Hydrogels Download PDF
Chapter  138:  Hydrolysis of Drugs Download PDF
Chapter  139:  Immunoassay Download PDF
Chapter  140:  Impurity Identification in Pharmaceuticals Download PDF
Chapter  141:  In Vitro-In Vivo Correlation Download PDF
Chapter  142:  Inhalation: Dry Powder Download PDF
Chapter  143:  Inhalation Download PDF
Chapter  144:  Injection Molding and its Drug Delivery Applications Download PDF
Chapter  145:  Iontophoresis Download PDF
Chapter  146:  Isolators for Pharmaceutical Application Download PDF
Chapter  147:  Laboratory Information Management System (LIMS) Download PDF
Chapter  148:  Lead Optimization in Pharmaceutical Discovery and Development Download PDF
Chapter  149:  Lens Care Products Download PDF
Chapter  150:  Liquid Oral Preparations Download PDF
Chapter  151:  Materials of Construction and Surface Finishes for the Pharmaceutical Industry Download PDF
Chapter  152:  Mathematical Modeling of Pharmaceutical Data Download PDF
Chapter  153:  Melt Processes for Oral Solid Dosage Forms Download PDF
Chapter  154:  Metabolite Identification in Drug Discovery Download PDF
Chapter  155:  Metered Dose Inhalers Download PDF
Chapter  156:  Microbial Control of Pharmaceuticals Download PDF
Chapter  157:  Microbiologic Monitoring of Controlled Processes Download PDF
Chapter  158:  Microcalorimetry in Pharmaceutical Development Download PDF
Chapter  159:  Microencapsulation Technology Download PDF
Chapter  160:  Microneedle Systems for Vaccine Delivery Download PDF
Chapter  161:  Microsphere Technology and Applications Download PDF
Chapter  162:  Milling of Active Pharmaceutical Ingredients Download PDF
Chapter  163:  Mixing and Segregation in Tumbling Blenders Download PDF
Chapter  164:  Moisture in Pharmaceutical Products Download PDF
Chapter  165:  Multivariate Statistical Methods Download PDF
Chapter  166:  Nanoparticle Engineering Download PDF
Chapter  167:  Nanoparticles as Drug Delivery Systems Download PDF
Chapter  168:  Neural Computing and Formulation Optimization Download PDF
Chapter  169:  Nonprescription Drugs Download PDF
Chapter  170:  Nutraceutical Supplements Download PDF
Chapter  171:  Optimization Methods Download PDF
Chapter  172:  Oral Lipid-Based Formulations Download PDF
Chapter  173:  Orally Disintegrating Tablets Download PDF
Chapter  174:  Orphan Drugs Download PDF
Chapter  175:  Otic Preparations Download PDF
Chapter  176:  Outsourcing of Pharmaceuticals Download PDF
Chapter  177:  Packaging Systems: Compendial Requirements Download PDF
Chapter  178:  Parenteral Formulations: Local Injection Site Reaction and Muscle Tolerance Download PDF
Chapter  179:  Particle Engineering Download PDF
Chapter  180:  Particle Shape Analysis Download PDF
Chapter  181:  Particle-Size Characterization Download PDF
Chapter  182:  Partition Coefficients Download PDF
Chapter  183:  Patents: United States Perspective Download PDF
Chapter  184:  Pelletization Techniques Download PDF
Chapter  185:  Peptides and Proteins: Buccal Absorption Download PDF
Chapter  186:  Peptides and Proteins: Nasal Absorption Download PDF
Chapter  187:  Peptides and Proteins: Non-Invasive Delivery Download PDF
Chapter  188:  Peptides and Proteins: Oral Absorption Download PDF
Chapter  189:  Peptides and Proteins: Physical and Chemical Stability Download PDF
Chapter  190:  Peptides and Proteins: Pulmonary Absorption Download PDF
Chapter  191:  Peptides and Proteins: Transdermal Absorption Download PDF
Chapter  192:  Pharmaceutical Excipient Testing–A Regulatory and Preclinical Perspective Download PDF
Chapter  193:  Pharmaceutical Quality Assurance Microbiology Laboratories Download PDF
Chapter  194:  Pharmacogenomics and Genomic Technologies Download PDF
Chapter  195:  Pharmacokinetic/Pharmacodynamic Modeling and Simulations in Drug Development Download PDF
Chapter  196:  Pharmacokinetics: Effects of Food and Fasting Download PDF
Chapter  197:  Pharmacopoeial Standards: European Pharmacopoeia Download PDF
Chapter  198:  Pharmacopeial Standards: Japanese Pharmacopeia Download PDF
Chapter  199:  Photodecomposition of Drugs Download PDF
Chapter  200:  Physiological Factors Affecting Oral Drug Delivery Download PDF
Chapter  201:  Pilot Plant Design Download PDF
Chapter  202:  Pilot Plant Operation Download PDF
Chapter  203:  Plants as Drugs Download PDF
Chapter  204:  Polymeric Delivery Systems for Poorly Soluble Drugs Download PDF
Chapter  205:  Polymers in Transdermal Delivery Systems Download PDF
Chapter  206:  Polymorphism and Solvatomorphism: Pharmaceutical Aspects Download PDF
Chapter  207:  Population Pharmacokinetics Download PDF
Chapter  208:  Powder Sampling Download PDF
Chapter  209:  Powders as Dosage Forms Download PDF
Chapter  210:  Process Chemistry in the Pharmaceutical Industry Download PDF
Chapter  211:  Prodrug Design Download PDF
Chapter  212:  Protein Binding of Drugs Download PDF
Chapter  213:  Proteomics: Pharmaceutical Applications Download PDF
Chapter  214:  Pyrogens and Endotoxin Detection Download PDF
Chapter  215:  Quality Assurance of Pharmaceuticals Download PDF
Chapter  216:  Quality by Design (QbD) and Analytical Method Development Download PDF
Chapter  217:  Quality by Design (QbD) in Freeze Drying Download PDF
Chapter  218:  Quality Target Product Profile (QTPP) for Pharmaceutical Packaging and Delivery Systems Download PDF
Chapter  219:  Radiolabeling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition Download PDF
Chapter  220:  Receptors for Drugs: Discovery in the Post-Genomic Era Download PDF
Chapter  221:  Rheology of Pharmaceutical Systems Download PDF
Chapter  222:  RNAi in Drug Development Download PDF
Chapter  223:  Roller Compaction Technology for the Pharmaceutical Industry Download PDF
Chapter  224:  Safety Assessment in Drug Development Download PDF
Chapter  225:  Salt Forms: Pharmaceutical Aspects Download PDF
Chapter  226:  Scale-Up and Post Approval Changes (SUPAC) Download PDF
Chapter  227:  Scale-Up of Solid Dispersions Download PDF
Chapter  228:  Scale-Up of Solid Dosage Forms Download PDF
Chapter  229:  Secondary Electron Microscopy in Pharmaceutical Technology Download PDF
Chapter  230:  Self-Injection Devices Download PDF
Chapter  231:  Semisolid Preparations Download PDF
Chapter  232:  Single-Use Processing in the Pharmaceutical Industry Download PDF
Chapter  233:  Solid-State NMR in the Characterization of Pharmaceutical Formulations Download PDF
Chapter  234:  Solubilization of Drugs in Aqueous Media Download PDF
Chapter  235:  Solubilizing Excipients in Pharmaceutical Formulations Download PDF
Chapter  236:  Spectroscopic Methods of Analysis: Atomic Absorption and Emission Spectrophotometry Download PDF
Chapter  237:  Spectroscopic Methods of Analysis: Diffuse Reflectance Spectroscopy Download PDF
Chapter  238:  Spectroscopic Methods of Analysis: Fluorescence Spectroscopy Download PDF
Chapter  239:  Spectroscopic Methods of Analysis: Infrared Spectroscopy Download PDF
Chapter  240:  Spectroscopic Methods of Analysis: Mass Spectrometry Download PDF
Chapter  241:  Spectroscopic Methods of Analysis: Near-Infrared Spectrometry Download PDF
Chapter  242:  Spectroscopic Methods of Analysis: Nuclear Magnetic Resonance Spectroscopy Download PDF
Chapter  243:  Spectroscopic Methods of Analysis: Ultraviolet and Visible Spectrophotometry Download PDF
Chapter  244:  Starches and Starch Derivatives Download PDF
Chapter  245:  Statistical Methods Download PDF
Chapter  246:  Statistical Outliers: Methods and Applications Download PDF
Chapter  247:  Statistical Process Control and Process Capability Download PDF
Chapter  248:  Sterilization and Aseptic Processing Download PDF
Chapter  249:  Sterilization: Dry Heat Download PDF
Chapter  250:  Sterilization: Ethylene Oxide Download PDF
Chapter  251:  Sterilization: Moist Heat Download PDF
Chapter  252:  Sterilization: Radiation Download PDF
Chapter  253:  Supercritical Fluid Technology in Pharmaceutical Research Download PDF
Chapter  254:  Superdisintegrants: Characterization and Function Download PDF
Chapter  255:  Surfactants in Pharmaceutical Products and Systems Download PDF
Chapter  256:  Suspensions Download PDF
Chapter  257:  Tablet Compression: Machine Theory, Design and Process Troubleshooting Download PDF
Chapter  258:  Tablet Formulation Download PDF
Chapter  259:  Tablet Manufacture Download PDF
Chapter  260:  Tablet Manufacture by Direct Compression Download PDF
Chapter  261:  Tablet Press Instrumentation Download PDF
Chapter  262:  Tablet Testing Download PDF
Chapter  263:  Technology Transfer Considerations for Pharmaceuticals Download PDF
Chapter  264:  Thermal Analysis of Drugs and Drug Products Download PDF
Chapter  265:  Tonicity Download PDF
Chapter  266:  Tooling for Tableting Download PDF
Chapter  267:  Trace-Level Impurity Analysis Download PDF
Chapter  268:  Transdermal Delivery Technologies Download PDF
Chapter  269:  Transdermal Delivery: Anatomical Site Influence Download PDF
Chapter  270:  Transdermal Drug Delivery using Sonophoresis Download PDF
Chapter  271:  Unit Processes in Pharmacy: Fundamentals Download PDF
Chapter  272:  Unit Processes in Pharmacy: Strategies for Integration of Unit Operations Download PDF
Chapter  273:  Vaccines and Other Immunological Products Download PDF
Chapter  274:  Validation of Pharmaceutical Processes Download PDF
Chapter  275:  Veterinary Dosage Forms Download PDF
Chapter  276:  Veterinary Pharmaceuticals: Factors Influencing their Development and Use Download PDF
Chapter  277:  Virtual Screening Download PDF
Chapter  278:  Water for Pharmaceuticals Download PDF
Chapter  279:  Water Sorption of Drugs and Dosage Forms Download PDF
Chapter  280:  Wet Granulation: End-Point Determination and Scale-Up Download PDF
Chapter  281:  World Health Organization (WHO): Global Harmonization of Requirements for and Regulation of Pharmaceutical Products Download PDF
Chapter  282:  X-Ray Powder Diffractometry Download PDF
Chapter  283:  Zeta Potential Download PDF
Index Download PDF
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