Neurotoxicants: Developmental Experimental Testing

Authored by: Vera Lucia S.S. de Castro

Encyclopedia of Environmental Management

Print publication date:  December  2012
Online publication date:  December  2012

Print ISBN: 9781439829271
eBook ISBN: 9781351235860
Adobe ISBN:


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The normal structure and function of the nervous system may be altered as a result of exposure to some pollutants before or after birth. The analysis of chemical pollutant effects is particularly relevant in assessing interference at the nervous system development. These pollutants, as pesticides, can be more toxic to the developing central nervous system than those affecting the adults depending on the exposure characteristics and period of vulnerability. Animal behavior might provide useful indicators or biomarkers for detecting harmful chemical contaminants. These biomarkers can evaluate alterations in sensory, motor, and cognitive functions in laboratory animals exposed to toxicants during nervous system development. However, the detection, measurement, and interpretation of developmental neurotoxicity effects depend on appropriate study design and execution.

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